NELL1 Protein

The NELL1 pathway involves a number of signaling and structural proteins essential for tissue growth and organization, suggesting that NELL1 is effective at restoring not only muscle mass, but also the function of injured tissues. Published peer-reviewed research shows NELL1 is essential in forming a proper extracellular matrix (ECM). The ECM provides both a structural framework and a signaling environment, the combination of which is necessary for control of several key events in tissue regeneration including cell survival, proliferation and differentiation. NELL1 enhances new blood vessel formation (angiogenesis) and controls inflammation, which are critical elements in treating severe radiation dermatitis, skeletal muscle wounds, cardiac tissue damaged by acute myocardial infarction (AMI), or heart attack.